MINNEAPOLIS (AP) ? A Minneapolis business owner who was one of five people gunned down by a newly fired employee was remembered Sunday as a generous man of humble beginnings.
More than 1,000 mourners attended the service for Reuven Rahamim, founder of Accent Signage Systems. Rahamim, three other Accent employees and a UPS driver making a delivery were killed at the company Thursday when police say Andrew Engeldinger, 36, began shooting. He had been fired before the rampage, Minnesota's deadliest workplace shooting.
Three other people were wounded in the attack before police say Engeldinger took his own life.
Rahamim, 61, of St. Louis Park, immigrated from Israel and spent three decades building Accent Signage Systems after starting it in his basement. The business employed 28 people as of July.
"Reuven had everyone's back," Rabbi Alexander Davis said at Sunday's service for Rahamim. "He was present in everyone's lives, and he wanted to make a difference in the world."
Rahamim will be buried later this week in Israel.
The company released a statement Sunday saying workers are "devastated," but will carry on in memory of their colleagues.
"This senseless act has devastated us, but it will not destroy us," the company said. "We fully intend to honor the memories of our colleagues and friends by continuing to grow the company they helped build through their hard work and dedication."
The statement gave no new details about the investigation or Engeldinger, and police had no new information Sunday.
"Out of respect for the police investigation, and with deep compassion for those who are mourning and still recovering, we will not be releasing additional information at this time," the company said.
A service also was planned Sunday for Rami Cooks, 62, an Accent worker from Minnetonka who has been described as Rahamim's right hand man. Cooks' family asked that the service remain private.
Services for two other workers are planned for this week. Ron Edberg, 58, of Brooklyn Center, will be remembered Tuesday, and the service for Jacob Beneke, 34, of Maple Grove, is Wednesday.
Funeral plans for UPS driver Keith Basinski, 50, of Spring Lake Park, haven't been publicized.
Two of the surviving victims remained hospitalized Sunday. Accent production manager Eric Rivers was still in critical condition and director of operations John Souter was in serious condition, according to Hennepin County Medical Center.
Those of us who love our pens know that they can be more than just a writing instrument that we toss out and replace with a new one?they can be great tools that help us work and feel more creative. That said, most of us don't want to drop hundreds of dollars on a pen if we don't have to, so this week we asked you which budget pens were the ones you make sure never to let someone borrow and walk away with. Let's take a look at the top five, based on your nominations.
As with many Hives of this type, we're grouping together some popular models into brands, mostly because many of the brands here have so many varied models (and you voted for them all) that we think it's better to cover more territory than less. Still, you offered up way more great pen nominations than we can feature here, but we only have room for the top five.
Pilot Pens (G2, V5/V7, Varsity, G-Tech/Hi-Tec)
Pilot pens were some of the first to show many of us that a writing implement could be more than just a utilitarian device. Whether you were introduced to your first Pilot pen in school or at work, you probably still remember your favorite, and many of you called out your faves?specifically the Pilot G2?for its affordability, its broad availability, and it's smooth, clean writing. Many of you also pointed out how great the V5 and V7 models, which have been around for ages, still are, and others noted that when you wanted a fountain pen, you can't go wrong with the Varsity disposable model. Excellent taste. Photo by hades2k.
Zebra Pens (Sarasa, F/G-301, F-701, F-402)
Many of Zebra's most popular models are known for their trademark all-steel, metallic design, and you may remember the first time you encountered one?if it was like the first time I picked one up, they were unlike any other pen you'd seen in a world of disposable plastic pens. They just look sharp and elegant, and using them is just as much fun. Not all of their models are that trademarked steel body though: the Zebra Sansa, for example, is fantastic gel pen with a transparent body and soft grip for smooth, comfortable writing. Many of you also praised Zebra for its portability and attractive design?most of their pens are unibody, and can slide into a pocket or bag without worrying you'll lose a cap in the process. Besides, they really do look and feel good to use. Photo by J Wynia.
Uniball Pens (Jetstream, Signo, Onyx, Vision)
Uniball pens come in multiple shapes, sizes, and form factors, but one thing is certain: you reall love them. Whether it's the quick-drying Jetstream series, designed for speedy writers who don't want their ink to smudge, or the rich, smooth black ink of the Signo and Gel lines, or the utility but smooth, free-flowing rollerball feel of the Vision and Onyx lines, Uniball has a pen engineered for whatever writing style you prefer, that's comfortable enough to use for long periods, and at a price point that makes sure you can pick up more than a few and keep them around your home or office. You could write with different Uniball models for weeks and still fall in love with each new one you tried. Photo by Brett Jordan.
Lamy Pens (Safari, Al-Star, Vista)
Lamy's line of modern, stainless steel, and brushed aluminum pens earned high praise from those of you who don't want to break the bank on your writing instruments, but don't want to sacrifice good-looking style and comfort either. Whether it's the minimal, solid-color-and-clip design of the Safari line of fountains, gels, and rollerballs, or it's the more metallic tones of the Al-Stars, or even the transparant Vistas, many of you approved of Lamy's affordability and smooth, elegant writing. Even the shapely, designer Accent line earned nominations, and we have to agree?they all look good, and write better. Photo by vinyleraser.
Sharpie Pens
Sharpie's best known for their permanent markers, but their new pens offer the same quality non-toxic, smear-proof ink that?at least in this case?won't bleed through the paper as you use it. Sharpie's medium and fine point pens come with soft tips for smooth, consistent writing, and the best part is that they're available virtually anywhere. No refills or fancy designs on these, but those of you who nominated them love them to the point where at least one of you said that if you used one, you'd never vote for anything else. Sharpie's had a rough road with some of their pens, but we have to say: Sharpie's newer pens are great, and well worth a shot, especially considering the price point. Photo by redspotted.
That's it! Now that you've seen the top five, it's time to put them to an all out vote to determine the winner.
We have plenty of honorable mentions this week, mostly because the voting was so ridiculously close that there were multiple ties. First, one goes to The Fischer Space Pen, which many of you nominated for its clean, metallic designs that range from utilitarian to bullet-shaped, and the fact that they can write at all angles. The price doesn't hurt, ranging around $20-$50 for most models, and hey-they work in space!
Also worth mentioning are Bic Pens, including the Atlantis, Cristal, and Round Stic, all of which many of you praised for their affordability, multiple varieties, colors, styles, and writing thicknesses depending on your preference, their super-broad availability, and their smooth feel while writing.
FInally, we want to give a shoutout to Pentel Pens, including the Energel and R.S.V.P, which both offer great style, bang for your buck, and smooth, clean writing when used. Again, they fell just shy of the votes required to make the top five, which should show you how large the volume of nominees this week really was.
We got a ton of great nominees this week?way more than we could feature, even though we wanted to. Have something to say about one of the contenders? Want to make the case for your personal favorite, even if it wasn't included in the list? Remember, the top five are based on your most popular nominations from the call for contenders thread from earlier in the week. Make your case for your favorite?or alternative?in the discussions below.
The Hive Five is based on reader nominations. As with most Hive Five posts, if your favorite was left out, it's not because we hate it?it's because it didn't get the nominations required in the call for contenders post to make the top five. We understand it's a bit of a popularity contest, but if you have a favorite, we want to hear about it. Have a suggestion for the Hive Five? Send us an email at tips+hivefive@lifehacker.com!
NEW YORK, Sept. 28, 2012 /PRNewswire/ -- There are two common dilemmas in the treatment of cancer today: the first is that many therapies, including chemotherapies and radiation can debilitate healthy cells, to the point of killing the person before defeating the cancer. The second problem is that many cancer cells, responding to a prevention drug, can quickly mutate to become immune and more resilient.
Recent advances in circulating tumor cell technology (CTC) however, headed by Dr. Daniel Haber, Director at Massachusetts General Hospital Cancer Center and Dr. Mehmet Toner, Director of the Center for BioMicroElectroMechanical Systems, address this mutation problem head on. Their research has also found support from The American Association of Cancer Research, the American Cancer Society and The Jeffrey Epstein VI Foundation, which supports cutting edge medical research around the world.
CTC is a simple blood test to detect circulating cancer cells. Using a microfluidic chip, the test isolates cancer cells in the blood and allows them to be purified to analyze their genetic structure. Although many challenges remain in the test, the advantages have already made a huge impact on the treatment of cancer. To date, the test has identified more than 1,200 cancer-causing genetic mutations, the largest collection in the world. The findings have led to a host of mutation specific targeted therapies including the use of reversible and irreversible inhibitors, which have been highly effective in tumor reduction. For instance, Dr. Haber's team recently found that gastric adenocarcinomas, stemming from amplification of the growth factor receptor gene c-MET, only respond to novel inhibitors of the MET tyrosine kinase, leading to the initiation of a genotype-directed clinical trial.
Critically, the CTC test also addresses the major problem of secondary and tertiary genetic mutation to treatment. For while targeted inhibitors can be highly effective in tumor shrinkage, almost all cancer cells quickly mutate to be resistant, reversing tumor reduction within six to eight months. Furthermore, resistance becomes effective from the slightest evolution. For example, approximately half of non-small cell lung cancer cases with mutations to EGFR TK inhibitors became resistant from a single mutation of T790M within the EGFR kinase domain. Indeed, the bulkier methionine residue at position T790M hinders interaction with the inhibitor, preventing binding to the EGFR kinase domain while preserving catalytic activity. An analogous mutation (T315I) in the BCR-ABL fusion kinase in chronic myelogenous leukemia cells renders them resistant to ABL kinase inhibitors, gleevec and dasatinib.
By extracting cancer cells from a CTC blood test however, a patient can be analyzed in genetic real time, meaning a continual genetic analysis to determine the first line of treatment and then a secondary or third line of treatment, as soon as any resistive mutations occur. In fact, since treatment can be tested on the patient's cells in vitro--and from a blood sample relatively quickly and accurately--as compared to a biopsy, any secondary or tertiary mutations detected in the cell culture, can be treated preemptively as part of the first line of attack, as a cocktail with the primary treatment or in immediate sequence. Unlike a blood test however, tumor biopsies can be hugely debilitating, costly, genetically outdated, not always easy to locate and can encourage metastasis of the tumor.
By using the microfluidic test, Dr. Haber's team has a growing catalog of secondary and tertiary mutations and has shown how several irreversible inhibitors produce significant, if not permanent anti-tumor activity on a variety of secondary mutations such as the EGFR receptor double mutation, L858R/T790M. Some of these irreversible inhibitors, namely HKI-272, EKB-569, BIBW2992, and PF00299804, are currently undergoing clinical testing.
Technically, the CTC microfluidic chip test works by taking only 10 milliliters of blood, containing about 80 billion cells. Magnetic beads on the chip are coated with antibodies that bind to both EpCAM positive and EpCAM negative cells (epithelial cell adhesion molecules), a common marker present on CTCs originating from epithelial cancers. The binding of antibodies, makes the CTC cells detectable and ready for extraction via purification.
The toxic effect of genetic therapies are significantly less than standard chemotherapy drugs, due to their receptor specificity, however toxicity is still a major hurdle and can cause heart disease, gastrointestinal damage and the development of other cancers. "The CTC test is not only increasingly specific to the mutation driving the cancer," Jeffrey Epstein countered, whose foundation supports cutting edge medical and science research around the world, "but doses can be closely minimized to tumor reduction and secondary treatments can be given in tandem or immediately thereafter."
Source: www.jeffreyepstein.org
www.jeffreyepstein.org
CONTACT: Christina Galbraith, The Jeffrey Epstein VI Foundation,+1-917-573-7604, http://www.jeffreyepstein.org
In my first month as the new Green party leader, I've spent lots of time talking about pressing economic and social issues - the need for the minimum wage to be a living wage, how benefits should be available to all who need them, and how costly and destructive the privatisation of the NHS will be.Active and spent nuclear fuel rods underwater. (Photograph: Timothy Fadek/Corbis)
But with the government's energy bill on the horizon, serious questions around the coalition's wobbly-looking commitment not to subsidise new nuclear, and an anti-nuclear protest at Hinkley Point on 8 October, I've also spent lots of my time explaining why I think renewable energy - wind, solar and, in the future, tide and wave - combined with energy conservation, provide an excellent way forward for British energy.
I talk about the fact that the first two are technologies that are ready to scale up right now, providing jobs and affordable supplies for Britain. And about the fact that we know exactly what all of their "fuel" supplies will cost indefinitely into the future - ie nothing.
I talk about the way they can provide a decentralised, resilient energy system that is able to withstand climate or other shocks. And I discuss how nuclear is a distraction from the need to promote and invest in renewables.
Fuelled by a fierce and well-funded industry lobby claiming that nuclear would address the dire, if exaggerated, warnings about "the lights going out", as well as the urgent need to reduce our greenhouse gas emissions, the nuclear idea has gained some traction recently in the UK.
So I think it is worth spending a little time talking about why nuclear power is the Betamax of the energy world - a technology that was briefly in the hunt, but now could be ready to fade away into a museum curiosity. And you don't have to just believe me on this - consider this recent front page from the Economist.
First, it is immensely and unpredictably expensive. Even a group called Supporters of Nuclear Energy is now questioning the cost of nuclear to the UK. Paying ?165/MWh for power from Hinkley Point would make new nuclear more costly than either onshore or offshore wind - a cost that would be felt in the pockets of millions of already hard-stretched British households.
The two European Pressurised Reactors, as proposed for Britain, now being built in Finland and France, are both already running four years behind their construction schedule, and at roughly double the original budget. The French National Audit Office recently recommended that the programme - the very one Britain is looking like signing up for - be abandoned.
Second, it is slow to build - very, very slow. The four new nuclear reactors built by EDF since 1990 have taken on average 14 years to completion and 17.5 years to come online. That's not nearly quick enough to meet Britain's needs, either for power or for emissions reduction.
Third, it is by its nature monopolistic. Enormously expensive and, technologically, immensely complicated, no community would be able to decide to install one even if they wanted to. Local communities aren't going to be able to install one to boost local education spending in the same way that a Scottish Green party councillor is suggesting with wind turbines in Aberdeenshire.
Fourth, it isn't renewable. Arguments are many and varied about the supplies of nuclear fuels and how long they might last, but whatever figures you accept, the fact is we're talking about a quite limited supply. But the wind and the sun are never going to run out - at least not in a time frame we have to worry about.
Fifth, it is unreliable. If a handful of plants are responsible for a large percentage of Britain's power, sudden shutdowns could have hugely disruptive effects - as sweating Japanese salarymen in their suddenly non-airconditioned offices found after the Fukushima disaster. A power system reliant on nuclear can never be a reliable, resilient system.
Then there is safety. There is, as we saw at Three Mile Island, Chernobyl and Fukushima, the potential for enormous catastrophe. Again, you'll find lots of arguments about just how many people died or were badly affected as a result of these catastrophes. But those who like to claim figures of near zero fail to mention the loss of homes and land, tens of thousands of people displaced, and agricultural land lost to use for centuries from the small land mass of Japan (an island nation pretty similar in scale to Britain).
But it is difficult to weigh the risks of rare yet highly catastrophic events, such as a full nuclear meltdown. The good news is that we don't have to - it doesn't even have to be part of the argument against nuclear power. The costs, the unreliability, and the slowness of nuclear power alone mean that it can't be the answer to Britain's energy needs.
If there weren't already a solution at hand, we'd have to be frantically hunting around for one. But the fact is that there is - renewables, combined with a serious drive for energy conservation, which would also have the added benefits of making our homes more comfortable and our air more breathable. And put money into the pockets of local communities, not export it to a multinational energy giant.
We need to stop getting distracted by this 20th-century Betamax option, and get on with putting in place the 21st-century renewables solution.
PHOENIX (Reuters) - A suspected carjacker shot himself to death after a police chase in Arizona on Friday in a grim spectacle aired on live television - sparking a quick on-air apology and waves of outrage across social media.
The man was seen on the Fox News Channel stumbling from a dark red vehicle into the desert near Phoenix, stopping a short distance away and then apparently pulling the trigger of a gun pointed to the right side of his head. He then crumpled face-forward into the ground.
Anchor Shepard Smith shouted, "Get off it!" repeatedly, apparently asking his control room to cut away from the shot. The network quickly cut to a commercial and when Smith returned, he apologized for the incident.
"We really messed up and we're all very sorry," Smith told viewers. "That didn't belong on TV. We took every precaution we knew how to take to keep that from being on TV. And I personally apologize to you that happened."
Social media erupted quickly with reaction to the televised incident, much of it negative.
"Cannot believe FOX let a live suicide air over their network, my heart literally sank watching that.. #appalled," said a Twitter user who identified herself as Kelcey Brand.
The Columbia Journalism Review asked in a tweet: "Who's worse? @FoxNews for airing the suicide, or @Buzzfeed for re-posting the video just in case you missed it the first time?"
Andrew Kaczynski, a reporter for BuzzFeed Politics, tweeted back to Columbia Journalism Review: "I prefer your whiny usually incorrect long form analysis pieces over your instant judgment."
Phoenix police spokesman Sergeant Tommy Thompson said the man, who was not immediately identified, was being pursued by officers after carjacking a 2008 Dodge Caliber, apparently the vehicle seen in the television broadcast.
Thompson said the man had taken the car at gunpoint from two people in west Phoenix about 11 a.m. local time and was chased by police through city streets and a state highway before ending up on a dirt road.
The man fired at officers and a police helicopter at one point during the pursuit, but there were no other injuries, Thompson said. He said the man died at the scene from a self-inflicted gunshot wound.
"We don't know why he shot himself right now," Thompson said. "That's something that we may find out once we find out with some more time. We're not there now."
(Additional reporting by Dan Whitcomb and Mary Slosson; Editing by Cynthia Johnston and Peter Cooney)
So you've got a shiny new iPhone 5, but you're already sick of the default "water ripple" wallpaper, and those old iPhone 4 wallpapers are too small. The web may not be teeming with iPhone 5-sized wallpapers yet, but here's where you can find one that suits your tastes?and how to crop one for yourself.
A lot of folks have already put together wallpapers for the iPhone 5, there just aren't as many as there are for other phones yet. A few searches brought up the following galleries, which already have quite a few iPhone 5-centric wallpapers:
Remember that some of these sites may contain NSFW images buried in the galleries, so be careful of that as you browse.
Of course, if none of those wallpapers suit you, you can always just make your own by cropping a desktop wallpaper down to iPhone size. Find a wallpaper you like and follow these steps:
Open your wallpaper in an image editor like the GIMP, Paint.NET, or even Preview on the Mac.
Crop the image to 1136x640.
Save the wallpaper and transfer it to your phone via Dropbox or email.
Set your new wallpaper in Settings > Wallpaper.
That's it! For more iPhone goodness, check out our guide to customizing your iPhone inside and out.
A number of European languages could eventually vanish from the Internet, suggests a new study conducted by European nonprofit META-NET. Languages such as Icelandic, Latvian and Lithuanian don't have enough speakers to gain traction as popular languages on the Web. The report goes so far as to say that German, Italian, Spanish and French could be at risk, too.
Each Fall, some of the best investment minds in the universe converge in New York City for the much anticipated Value Investing Congress.
Smart market?participants?jump at the chance to attend the event and there are always multiple big stories that trickle out and move markets.
StockTwits will be the official microblogger of the event in New York City this coming Monday and Tuesday October 1 & 2.
Josh Brown (aka?@reformedbroker) and I (@ppearlman) will be there tweeting it and interviewing participants but if you can make it live, it?s a hot ticket for good reason.
The cast is stellar.
David Einhorn, President of Greenlight Capital
Bill Ackman, Managing Member and Portfolio Manager of Pershing Square
Barry Rosenstein, Founder and Managing Partner of JANA Partners
Bob Robotti, Founder and CIO of Robotti & Company Advisors
Whitney R. Tilson, Founder and Managing Partner of T2 Partners
John Mauldin, President of Millenium Wave Advisors
Glenn Tongue, Managing Partner of T2 Partners
Alexander Roepers, President of Atlantic Investment Management
Guy Gottfried, Founder and Manager of Rational Investment Group
Jeffrey W. Ubben, Founder, Chief Executive Officer & Chief Investment Officer of ValueAct Capital
Lloyd Khaner, General Partner of Khaner Capital
Kian Ghazi, Founder and Managing Partner of Hawkshaw Capital Management
Mick McGuire, Founder and Managing Member of Marcato Capital Management
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The information in this blog post represents my own opinions and does not contain a recommendation for any particular security or investment. I or my affiliates may hold positions or other interests in securities mentioned in the Blog, please see my Disclaimer page for my full disclaimer.
?Do the Warrior!? someone shouts at Barbara Teusink as she paddles out into the lake. Teusink has led our class in trying new things on the stand-up paddleboards on a sunny Saturday morning. Teusink obliges, running through a series of yoga poses. We are all clapping and cheering as each new participant wobbles and then stands up on the boards. No trash talking here ? it?s all about support at the South Carolina Wildlife Federation?s annual women?s retreat.
The newest bundle of DRM-free ebooks from StoryBundle is available now, this time focusing on the crime and thriller genre. As mentioned last time, StoryBundle offers packages of quality indie books for a pay-what-you-like pricetag, vetted and brought to you by former Lifehacker Jason Chen. [StoryBundle]
On September 14, the Office of Management and Budget (OMB) released its recommendations for budget cuts that include withholding parts of the Sport Fish Restoration and Boating Trust Fund, a move that would have a significant effect on fisheries conservation and the jobs it supports. OMB?s action was triggered by the failure of the Congress and the Administration to enact a plan to reduce the deficit by $1.2 trillion, as required by the Budget Control Act of 2011.
?The angling and boating community was shocked to learn that for the first time in its 62-year history, the Sport Fish Restoration and Boating Trust Fund ? the backbone of fisheries conservation in the United States ? is recommended for a cut under sequestration totaling $34 million,? said Gordon Robertson, vice president of the American Sportfishing Association.
Robertson further said, ?This conservation trust fund, established in 1950 with the support of industry, anglers and state conservation agencies, is an outstanding example of what good government should be and is the backbone of the user-pay model of funding conservation in this nation. It is important that it remain untouched. The sportfishing and boating communities are ready to work with Congress and the Administration to solve this problem.?
The Sport Fish Restoration Act of 1950 placed a federal excise tax on all recreational fishing equipment, which manufacturers pay and is then incorporated into the cost of the equipment that anglers purchase. In 1984 the Act was amended to include that part of the federal gasoline fuel tax attributable to motor boat use. The total annual value of the Trust Fund is approximately $650 million. The monies from the fund are apportioned to state conservation agencies for sport fish restoration, boating safety, angler and boater access and other fishing and boating programs.
?When anglers and boaters pay the equipment tax or the fuel tax they are doing so with the understanding that this money is going to a trust fund dedicated ? by law ? to the resources they enjoy,? said Robertson. ?Withholding funds from this essential program at a time when state fishery programs are already struggling to ensure the best quality service to anglers and resource management will only cause fishery resources to suffer even more and cause job losses associated with the loss of recreation fishing boating programs. The sportfishing and boating industries as well as anglers and boaters themselves fail to understand how cutting a user-pay trust fund helps the economy.?
Recreational fishing contributes $125 billion each year to the nation?s economy and supports more than one million jobs. Since its inception, the Sport Fish Restoration Act has pumped $7 billion into habitat restoration, access and boating safety programs.
The Sport Fish Restoration and Boating Trust Fund?s older sibling, the Wildlife Restoration Act of 1936, after which the Sportfish Trust Fund was patterned, is slated for a $31 million freeze. That Act is funded by hunters and men and women who engage in the shooting sports and archery, who pay a similar tax to support wildlife restoration. ?This level of cuts to conservation programs that pay their own way is unprecedented and all anglers, hunters and shooting sports enthusiasts must speak up to prevent these cuts,? Robertson concluded.
Along with these two cornerstone conservation acts, many other critical conservation funds are also listed for significant cuts. Congress, with the cooperation of the Administration, must address the sequestration schedule and they will not occur until after the elections and possibly not until early 2013 and with a new Congress.
?We encourage all anglers to go to www.KeepAmericaFishing.org for information about when Congress may act and when anglers should speak up to maintain critical conservation funding,? Robertson said.
The fall TV season is upon us and we have responded accordingly with a plus-size episode of the EHD podcast. We've got a good mix of old and new, with news about DirecTV's DVRs, TiVo settling a patent lawsuit and our review of the Vizio Co-Star Google TV box. The NFL Network is finally on Time Warner Cable, but we pause the celebration to remember NFL Films pioneer Steve Sabol. There's Apple TV, Hulu Plus, HBO Go and Showtime Social updates to go around as well, press play to find out what's new.
Get the podcast [iTunes] Subscribe to the Podcast directly in iTunes (MP3). [RSS - AAC] Enhanced feed, subscribe to this with iTunes. [RSS - MP3] Add the Engadget HD Podcast feed to your RSS aggregator [Zune] Subscribe to the Podcast directly in the Zune Marketplace [MP3] Download the show (MP3).
Hosts: Ben Drawbaugh (@bjdraw), Richard Lawler (@rjcc)
On our summer family vacation last month, we traveled through the east coast and I can?t recall a time when we crossed over more bridges. Some bridges were old, some were brand new, some low and some very high. And with each crossing, my wife would sink deeper into the passenger seat with eyes closed while our kids pointed out some of the sights only seen at higher elevations thanks to the bridge. Too bad Pam didn?t get a chance to see those sights.
I?m not sure, but my wife might have gephyrophobia, the fear of crossing bridges.
More on business development from Nick Keseric:?If Business Development Is a Circus at Your Firm??? |? My Attitude??? What?s Wrong with My @#$%! Attitude?? |? Curious Minds Want to Know: Are You Helping or Selling?? |? The Six-Step Roadmap for CPA Change Agents? |? 20 Biz Dev Ideas for Your Career and Your Firm? |
In business development, if we have gephyrophobia, we shouldn?t be in business development. In business development we need to cross various bridges in the sales and marketing process each and every day.
In order to increase our revenues, development new clients, maintain current clients and cultivate referral sources, we may want to look at few of these bridges we will need to cross? without eyes closed or sinking into our chair behind our desk:
Bridge of Adoptability : Given the competition by quality firms in the accounting profession, there is the greater ?need to look to adopt to the needs of our prospects and clients more so than ever and not only in pricing. Just saying, ?We don?t do that? could be the last thing you say to a longtime client. Seek out ways to cross over to get what they want completed. Creativity. Innovation. And yes, the old, ?think outside the box? to get the job completed.
Bridge of Communications:? Both internally to colleagues and externally to prospects, clients and referral sources. Let others know what is going on. Keep them informed? not surprised.
Bridge of Information: Be the source of answers and solutions directly or incorporate a colleague who can assist your clients, prospects and or referral sources with their questions.? By bringing in a colleague, you are showing the teamwork approach within your firm. You can say it, but when you demonstrate, it becomes more powerful.
Bridge of Technology: While a face to face meeting is hard to beat for business development, being aware of the latest technology used in business development is no longer a luxury? it is a necessity. Keep updated of that is available. Pagers. Car phones. Remember them? All had their day but technology evolves.
Bridge of Enthusiasm: Perception.It?s all about being welcoming and the willingness to help. We alone control this. Not a marketing or business plan. Our spirit inside of us controls how we project ourselves as well as our firm to others. Being positive sells.
Bridge of Trust: In order to convert prospects into clients, there needs to be trust. And while everyone will have their own definition of trust, the end-results are the same. There is something that occurs over a period of time that you conveyed or did something to a prospect that they feel confident (trust) with you and your firm.
Bridge of Connections:? This is your network. Each day try to grow your network as you never know when you may need that person and their expertise. Be visible in your business community and your own community. Be seen and be heard.
Bridge of Determination: Business development is not easy and is filled with detours of unanswered voicemails, tossed out letters, deleted emails, cancelled meetings and having to pick yourself off of the ground. But your determination will bring you closer one thing? success.
Bridge of Follow Up: If you don?t cross this bridge, all of your travels towards a prospect, client or referral source were wasted. The bridge of follow up is your main route to new revenues.
If firms don?t cross over these and other bridges in business development like growing accounting firms do, the prospects, clients or referral sources may indeed think your firm has gephyrophobia and view your firm as: CAUTION ? BRIDGE OUT.
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Nick Keseric is director of practice growth for the Orland Park, Ill., accounting firm MPS and a member and director of marketing development for MPS Capital Advisors LLC, at www.mpscpa.com
[unable to retrieve full-text content]Vu Nhu Thang, head of the Institute of Strategy and Policy on Finance under the Ministry of Finance, said the average State budget revenue in the last ten years stood at 26.6% of GDP, in which revenue from taxes and fees ...
Contact: Kevin Mayhood kevin.mayhood@case.edu 216-368-4442 Case Western Reserve University
Nanochains mark micrometastases for early diagnosis, treatment
Malignant cells that leave a primary tumor, travel the bloodstream and grow out of control in new locations cause the vast majority of cancer deaths. New nanotechnology developed at Case Western Reserve University detects these metastases in mouse models of breast cancer far earlier than current methods, a step toward earlier, life-saving diagnosis and treatment.
A team of scientists, engineers and students across five disciplines built nanochains that home in on metastases before they've grown into new tissues, and, through magnetic resonance imaging, detect their locations.
Images of the precise location and extent of metastases could be used to guide surgery or ablation, or the same technology used to find the cancer could be used to deliver cancer-killing drugs directly to the cells before a tumor forms, the researchers suggest.
The work is described in this week's online issue of the American Chemical Society journal ACS Nano.
"Micrometastases can't be seen with the naked eye, but you have to catch them at this stage see the exact spots they're located and see them all," said Efstathios Karathanasis, assistant professor of biomedical engineering and radiology, and senior author. "Even if you miss only one, you prolong survival, but one metastasis can still kill."
Karathanasis worked with research associate Pubudu M. Peiris, graduate student Randall Toy; undergraduate students Elizabeth Doolittle, Jenna Pansky, Aaron Abramowski, Morgan Tam, Peter Vicente, Emily Tran, Elliott Hayden and Andrew Camann; medical student Zachary Berman, senior research associate Bernadette O. Erokwu, biomedical engineering professor David Wilson, chemical engineering associate professor Harihara Baskaran; and, from the Case Western Reserve School of Medicine, radiology assistant professor Chris A. Flask and pharmacology associate professor and department vice chair Ruth A. Keri.
Tumor detection technologies fail to uncover cancer cells that have taken hold in new locations because young metastases don't behave the same as established tumors.
After a breast cancer cell enters the bloodstream, it most often stops in the liver, spleen or lungs and begins overexpressing surface molecules called integrins. Integrins act as a glue between the cancer cell and the lining of a blood vessel that feeds the organ.
"We target integrins," Karathanasis said. "Normal blood vessel walls don't present integrins towards the blood site unless cancer cells attach there."
To home in on the cancer marker, the researchers first needed to build a nano device that would drift out of the central flow of the blood stream and to the blood vessel walls. The most common shape of nanoparticles is a sphere, but a sphere tends to go with the flow.
Karathanasis' team tailored nanoparticles to connect one to another much like a stack of Legos. Due to its size and shape, the oblong chain tumbles out of the main current and skirts along vessel walls.
The exterior of the chain has multiple sites designed to bind with integrins. Once one site latches on, others grab hold. Compared to nanospheres, the chains' attachment rate in flow tests was nearly 10-fold higher.
To enable a doctor to see where a relative few cancer cells sit in a sea of healthy cells, the scientists incorporated fluorescent markers and, to make the nanochains more visible in magnetic resonance imaging, four links made of iron oxide.
Next, the team tested the chains in a mouse model of an aggressive form of breast cancer that metastasizes to sites and organs much the same way it does in humans.
From established research, they knew metastases would be present five weeks into the modeling. They injected nanochains into the bloodstream and, within an hour, two imaging techniques - fluorescence molecular tomography and MRI's - showed where traveling cancer cells had established footholds, primarily in the liver, lungs and spleen.
The metastases located using the nanochains ranged from .2 to 2 millimeters across.
Later imaging at high magnification showed that these metastatic cancer cells were found mostly in the blood vessel walls, before they'd had time to grow into organ tissue.
"Once metastatic cells move into the tissue, develop their own microenvironment, and grow into a 1-centimeter lesion, it typically indicates a late stage of metastatic disease which has an unfavorable outcome," Karathanasis said.
According to the American Cancer Society, the 5-year survival rate of breast cancer patients sharply decreases from 98 percent in cases that catch the disease when it has produced only a localized primary lesion to 23 percent in cases in which distant large metastases have grown.
Now that they've proved the concept works, the team is bringing clinical radiologists on board led by Vikas Gulani, assistant professor of radiology. Their job is to help with a new study, calculating how much new cancer the technology finds and misses.
###
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Contact: Kevin Mayhood kevin.mayhood@case.edu 216-368-4442 Case Western Reserve University
Nanochains mark micrometastases for early diagnosis, treatment
Malignant cells that leave a primary tumor, travel the bloodstream and grow out of control in new locations cause the vast majority of cancer deaths. New nanotechnology developed at Case Western Reserve University detects these metastases in mouse models of breast cancer far earlier than current methods, a step toward earlier, life-saving diagnosis and treatment.
A team of scientists, engineers and students across five disciplines built nanochains that home in on metastases before they've grown into new tissues, and, through magnetic resonance imaging, detect their locations.
Images of the precise location and extent of metastases could be used to guide surgery or ablation, or the same technology used to find the cancer could be used to deliver cancer-killing drugs directly to the cells before a tumor forms, the researchers suggest.
The work is described in this week's online issue of the American Chemical Society journal ACS Nano.
"Micrometastases can't be seen with the naked eye, but you have to catch them at this stage see the exact spots they're located and see them all," said Efstathios Karathanasis, assistant professor of biomedical engineering and radiology, and senior author. "Even if you miss only one, you prolong survival, but one metastasis can still kill."
Karathanasis worked with research associate Pubudu M. Peiris, graduate student Randall Toy; undergraduate students Elizabeth Doolittle, Jenna Pansky, Aaron Abramowski, Morgan Tam, Peter Vicente, Emily Tran, Elliott Hayden and Andrew Camann; medical student Zachary Berman, senior research associate Bernadette O. Erokwu, biomedical engineering professor David Wilson, chemical engineering associate professor Harihara Baskaran; and, from the Case Western Reserve School of Medicine, radiology assistant professor Chris A. Flask and pharmacology associate professor and department vice chair Ruth A. Keri.
Tumor detection technologies fail to uncover cancer cells that have taken hold in new locations because young metastases don't behave the same as established tumors.
After a breast cancer cell enters the bloodstream, it most often stops in the liver, spleen or lungs and begins overexpressing surface molecules called integrins. Integrins act as a glue between the cancer cell and the lining of a blood vessel that feeds the organ.
"We target integrins," Karathanasis said. "Normal blood vessel walls don't present integrins towards the blood site unless cancer cells attach there."
To home in on the cancer marker, the researchers first needed to build a nano device that would drift out of the central flow of the blood stream and to the blood vessel walls. The most common shape of nanoparticles is a sphere, but a sphere tends to go with the flow.
Karathanasis' team tailored nanoparticles to connect one to another much like a stack of Legos. Due to its size and shape, the oblong chain tumbles out of the main current and skirts along vessel walls.
The exterior of the chain has multiple sites designed to bind with integrins. Once one site latches on, others grab hold. Compared to nanospheres, the chains' attachment rate in flow tests was nearly 10-fold higher.
To enable a doctor to see where a relative few cancer cells sit in a sea of healthy cells, the scientists incorporated fluorescent markers and, to make the nanochains more visible in magnetic resonance imaging, four links made of iron oxide.
Next, the team tested the chains in a mouse model of an aggressive form of breast cancer that metastasizes to sites and organs much the same way it does in humans.
From established research, they knew metastases would be present five weeks into the modeling. They injected nanochains into the bloodstream and, within an hour, two imaging techniques - fluorescence molecular tomography and MRI's - showed where traveling cancer cells had established footholds, primarily in the liver, lungs and spleen.
The metastases located using the nanochains ranged from .2 to 2 millimeters across.
Later imaging at high magnification showed that these metastatic cancer cells were found mostly in the blood vessel walls, before they'd had time to grow into organ tissue.
"Once metastatic cells move into the tissue, develop their own microenvironment, and grow into a 1-centimeter lesion, it typically indicates a late stage of metastatic disease which has an unfavorable outcome," Karathanasis said.
According to the American Cancer Society, the 5-year survival rate of breast cancer patients sharply decreases from 98 percent in cases that catch the disease when it has produced only a localized primary lesion to 23 percent in cases in which distant large metastases have grown.
Now that they've proved the concept works, the team is bringing clinical radiologists on board led by Vikas Gulani, assistant professor of radiology. Their job is to help with a new study, calculating how much new cancer the technology finds and misses.
###
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Flags wave as Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks at Pueblo Weisbrod Aircraft Museum in Pueblo, Colo., Monday, Sept. 24, 2012. (AP Photo/Bryan Oller)
Flags wave as Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks at Pueblo Weisbrod Aircraft Museum in Pueblo, Colo., Monday, Sept. 24, 2012. (AP Photo/Bryan Oller)
President Barack Obama and first lady Michelle Obama appear on the ABC Television show ?The View? in New York, Monday, Sept. 24, 2012. (AP Photo/Pablo Martinez Monsivais)
Republican presidential candidate, former Massachusetts Gov. Mitt Romney campaigns in Pueblo, Colo., Monday, Sept. 24, 2012. (AP Photo/Charles Dharapak)
President Barack Obama waves as he boards Air Force Once prior to leaving from Andrews Air Force Base, Md., Monday, Sept. 24, 2012, for a trip to New York City. (AP Photo/Manuel Balce Ceneta)
President Barack Obama point to people on the South Lawn of the White House in Washington, Monday, Sept. 24, 2012, as he walks from the Oval Office to Marine One, Monday, Sept. 24, 2012, en route to New York. (AP Photo/Carolyn Kaster)
PUEBLO, Colo. (AP) ? Mitt Romney led a chorus of Republican criticism of the administration's foreign policy on Monday, accusing President Barack Obama of minimizing the recent killing of the U.S. ambassador to Libya as a mere "bump in the road" rather than part of a chain of events that threatens American interests.
White House press secretary Jay Carney called the accusations "desperate and offensive" as Romney and his allies sought to gain political advantage in the latter stages of a political campaign that seems to be trending Obama's way.
The president did not comment on the criticism when he and first lady Michelle Obama taped an appearance on ABC's "The View" that blended the personal with the political. Asked if a Romney presidency would be a disaster, Obama said the nation can "survive a lot." He added: "The American people don't want to just survive, we want to thrive."
The back and forth on foreign policy occurred as Romney said he was shifting to a more energetic schedule of public campaign events, bidding to reverse recent erosion in battleground state polls. After days spent largely raising campaign cash ? and trying to minimize the fallout from one speech to donors last spring ? he pledged to make the case for "real and positive change."
While national polls make the race exceedingly close, Obama has gained ground on Romney in many recent surveys when potential voters are asked to compare the two rivals in their ability to fix the economy. Sluggish growth and national unemployment of 8.1 percent make the economy by far the dominant issue in the race, and the two men have focused much of their time and advertising budgets on highlighting their differences on taxes, spending and plans for job creation.
The same polls show Obama with a healthy lead over Romney when voters are asked which candidate is better equipped to handle foreign policy, and the president has not shied away from trumpeting his decision to order the secret mission by U.S. forces that killed terrorism mastermind Osama bin Laden in his Pakistani hideout more than a year ago.
At the same time, Romney's advisers say voters are more inclined to question Obama's handling of foreign policy after the attack on the U.S. Consulate in Benghazi, Libya, earlier this month resulted in the death of the U.S. ambassador and three other Americans.
Not only Romney, but other Republicans, as well, challenged Obama on foreign policy on Monday.
In a conference call with reporters, Rep. Eric Cantor, R-Va., the House majority leader, said: "Israel continues to find itself on the receiving end of harsh language by the president of the White House. ... There is a somewhat continued pattern of throwing Israel under the bus when Israel stands as our closest ally."
And the National Republican Senatorial Committee issued challenges to Democratic candidates in several races to "share their view" on Obama's remarks in an interview with CBS' "60 Minutes" over the weekend.
In the interview itself, Obama was responding when asked if recent events in the Middle East gave him pause for supporting governments that came to power following a wave of regime changes known as the Arab Spring.
He said he has long noted that events were going to be rocky, adding that the question itself "presumes that somehow we could have stopped this wave of change."
"I think it was absolutely the right thing for us to align ourselves with democracy, universal rights. ... But I was pretty certain and continue to be pretty certain that there are going to be bumps in the road because ? you know, in a lot of these places ? the one organizing principle has been Islam."
He added: "There are strains of extremism, and anti-Americans, and anti-Western sentiments and you know can be tapped into by demagogues."
Romney was eager to talk about the topic, squeezing interviews with three television networks into his schedule and touching on the subject at the beginning of a rally in Pueblo, Colo.
"I can't imagine saying something like the assassination of ambassadors is a bump in the road, when you look at the entire context, the assassination, the Muslim Brotherhood president being elected in Egypt, 20,000 people killed in Syria, Iran close to becoming a nuclear nation, that these are far from being bumps in the road," he told ABC.
"They represent events that are spinning out of the kind of influence we'd like to have. We're at the mercy of events rather than shaping the events in the Middle East."
U.S. officials are investigating the deaths in Libya, which occurred when the consulate was breached.
In his appearance on "The View," the president avoided a direct answer when asked if the attack had been terrorism.
"There's no doubt that the kind of weapons that were used, the ongoing assault, that it wasn't just a mob action. What's clear is that, around the world, there are still a lot of threats out there," he said.
Romney intends to return to the subject of international affairs and discuss foreign aid, trade agreements and international development when he addresses the Clinton Global Initiative in New York on Tuesday, according to a person familiar with the campaign's thinking.
Romney, like Cantor, took a slap Monday at Obama's handling of relations with Israel.
"The president doesn't have time to actually spend time with leaders of these nations, particularly Bibi Netanyahu. I find that very troubling," he said.
In a campaign setting records for television advertising, both campaigns released new commercials during the day as Obama conceded some of his own had gone too far. "You know, do we see sometimes us going overboard in our campaign, the mistakes that are made in areas where there is no doubt that somebody could dispute how we are presenting things ? that happens in politics," he said during the "60 Minutes" taping. The remark was not part of the broadcast, but was posted to the CBS website.
___
AP White House Correspondent Ben Feller contributed from New York; Associated Press writers Jim Kuhnhenn and Philip Elliott contributed from Washington. Espo reported from Washington.
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Saturday Highlights: The Verizon iPhone 5 is arriving to customers unlocked; CNET analyzes Tim Cook's calculated risk in getting rid of Google Maps in iOS 6; Reuters believes iPhone 5 defines success, Tim Cook-style; Apple seeks another $700m from Samsung, with reports from WSJ and FOSS Patents; Apple rolls out four new iPhone 5 ads; PatentBolt reports on smuggled iPhone 5s reaching China; Dan Frommer at Splat F reviews his first hour with the iPhone 5 and finds the brushed aluminum to be very fragile; AnandTech provides a comprehensive iPhone 5 Performance Review; Gizmodo compares the iPhone 5's camera performance against the leading competitors; The Macalope picks apart a Forbes writer; Mike Elgan at Cult of Mac positions that Apple's obsession with Google is hurting Apple (sic).
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News
"Final Builds of 10.8.2 and 10.7.5 Maintain OS X Battery Life"?The Mac Observer?9/22
"Apple goes against grain, extends support for Snow Leopard: If Apple had done the expected and not patched Snow Leopard, the number of users running a retired edition of OS X would have ballooned to 47 percent"?Computerworld?9/21
"Flashback malware for OS X appears to be going extinct"?MacFixIt?9/21
AppleCare/Troubleshooting
"Aperture 3.4: May quit unexpectedly on launch after updating"?Apple Support?9/22
"Q&A MacFixIt Answers: We answer reader questions about using Maps from iOS 5 on iOS 6, Time Machine backups, and more."?CNET Reviews?9/21
"Mac Files of the Weird: iCal Calendar not Available when Creating new Event"?Run Around Tech?9/21
Reviews/How-To/Tips
"How To Use Your Mac Dock to Toggle Login Items & Other Dock Tips"?The Mac Observer?9/22
"Speed testing Windows 8 and OS X Mountain Lion"?ThinkDigit?9/22
"Head-to-Head: iTunes Match versus Amazon Cloud Player"?TechHive?9/21
"Ask the iTunes Guy: More iTunes Store questions"?Macworld?9/21
"MacPhun Snapheal 2.0 review: The new version of Snapheal has a range of brush-based adjustments to allow for more fine control over image correction."?Macworld UK?9/21
"Gemini For Mac OS X Great At Blasting Away Duplicate Files"?MacNews?9/21
"Bypass The Mac App Store To Update Mountain Lion Software"?Cult of Mac?9/21
"Growl On The Mac Is Back! This Time It Works With Notification Center In OS X Mountain Lion"?Mac 360?9/21
"Did You Really Click That Button? Should You Click Again? Use This Click Tool On Your Mac To Know"?Mac 360?9/21
"End The Background Noise On Skype Or FaceTime With Push To Talk On Your Mac"?McSolo?9/21
"Are Email Attachments Driving You Nuts? Try The Attachment Tamer On Your Mac"?Mac 360?9/21
"Writedown Is The Inexpensive Mac Text Editor That Uses Markdown"?NoodleMac?9/21
Op/Ed
"iOS / Mac Dev. creates MAME arcade machine powered by an iPhone"?9 to 5 Mac?9/22
"Apple Most Valuable Brand, OS X 10.8.2 Update, Launchpad Manager, and More"?Low End Mac?9/21
"To Defrag, Or Not To Defrag Your Mac? That's The Friday Question"?BohemianBoomer?9/21
"On Cleaning Mac Caches, Customizing, Optimizing, And Disaster Preparation (oh, and a note on viruses)"?TeraTalks?9/21
"Microsoft Office for Mac Updated for Retina Display, Secondary Mobile Displays, and More"?Low End Mac?9/21
"Apimac Secret Folder is now ready for OS X Mountain Lion's Gatekeeper"?Apimac?9/21
"BuildEdge PLAN for SketchUp Mac Beta now available"?Architosh?9/21
"Apple co-founder sees future as computer's pet"?Brisbane Times?6:48 AM
"T-Mobile USA invites iPhone users to HSPA+ networks"?PCWorld?9/22
"The iPhone 5 scene at Apple's retail stores"?Macworld?9/22
"Slick Window Display Promotes New iPhone 5"?ifoAppleStore?9/22
"50 iPhone 5s stolen from London store in worldwide spate"?Crave @ CNET?9/22
"Wireless carriers hope to temper iPhone 5 margin pain"?Reuters?9/22
"iPhone 5 matches monthlong sales figures for 4S in just 3 days: ComScore report says the first three days of online preorders for the iPhone 5 matched the earlier Apple record set by the iPhone 4S over the course of a month."?CNET News?9/21
"Transit app developers see iOS 6 Maps as a chance to shine"?Ars Technica?9/21
"Early iPhone 5 Purchases Trend Toward iPhone 4S Upgraders and Black Models Amid Long Lines"?MacRumors?9/21
"Apple union's 'Day of Solidarity' to protest working conditions: As the iPhone 5 hits stores today, an Apple workers union asks store employees to demand better conditions in France and at Foxconn."?CNET News?9/21
"Apple fans and critics converge in Paris for iPhone 5"?CNET News?9/21
"Labor protest at Apple iPhone party in Paris"?Reuters?9/21
"iPhone 5 launch-day mania: Apple's map troubles haven't stopped the iPhone 5 launch-day crowds. CNET Update talks to fanatics in line at the Cube in New York City."?CNET News?9/21
"Apple iPhone 5 launch: Queues go global as Samsung offends millions"?Computerworld?9/21
"iPhone 5 launch draws Apple fans across the world"?New York Post?9/21
"A short, wonderful tale of iPhone 5 lines across North America [Slideshow]?BetaNews?9/21
"Live on Fifth Avenue from Apple's iPhone 5 launch (updated)"?Fortune?9/21
"Hundreds lining up in Sacramento to buy iPhone 5"?Sacramento Bee?9/21
"iPhone 5 launch live from Apple Store Montreal"?iMore?9/21
"iPhone 5 buyers flood stores, jam phone lines as they rush to purchase, activate smartphones"?Vancouver Sun?9/21
"iPhone 5 launch live from the Regent Street Apple Store in London"?iMore?9/21
"Waiting For The iPhone 5 (Video)"?Forbes?9/21
"iPhone 5 queue hysteria captured in launch-day photos"?Crave @ CNET?9/21
"iPhone 5 lines from around the world [Video]?BGR?9/21
"Wal-Mart, Apple, Amazon and Google: In corporate battles, customers may be casualties"?Washington Post [Free Registration Required]?9/21
"London iPhone 5 Madness: 'You must be CRAZY to buy Apple'"?The Register?9/21
"Woz on iPhone in 40 years: 'I won't want you humans'"?SlashGear?9/21
"Woz in Brisbane, Australia with his iPhone 5 (with video)"?MacDailyNews?9/21
"Tales From The Front Of The iPhone 5 Line: Stick It In My Veins"?TechCrunch?9/21
"Singapore lines up for the iPhone 5"?CNET News?9/21
"Crowds queue to snap up latest iPhone"?Financial Times [Paid Membership Required]?9/21
"Sprint Nearly Sold Out of iPhone 5 at Many East Coast Spots"?AllThingsD?9/21
"Best Buy, other retailers delaying iPhone 5 preorders"?Electronista?9/21
"Smuggled iPhone 5s Sell for as Much as $3,700 in Moscow"?ABCNews?9/21
"Smugglers take iPhone 5 to China, but supplies thin"?Reuters?9/21
"Apple store assistant sought after hundreds of iPhone 5s are stolen"?The Independent?9/21
"Burglars in Japan First to Get Hands on iPhone 5"?WSJ Blogs?9/21
"Look At All These iPhone 5s Flooding FedEx's Distribution Center [Image]?Cult of Mac?9/21
"Marketers hijack iPhone 5 launch"?Financial Times [Paid Membership Required]?9/21
"Apple's Siri continues dominance over Samsung's S Voice"?Electronista?9/21
"New Google Voice Search, Siri are closely matched (hands-on)"?CNET?9/21
"Google's November Assault on Microsoft and Apple"?TheStreet?9/21
"London Underground offers offline maps to those who updated to iOS6 and no longer have schedules"?9 to 5 Mac?9/21
"Starbucks to support Passbook in iOS 6 by end of September"?Macworld?9/21
"Airlines, Theaters, More Sign On for Apple's Passbook"?PC Magazine?9/21
"Worry not, Snapseed lovers: Google's Vic Gundotra says Nik Software's products will live on"?The Next Web?9/21
"Apple rep pitches iPad possibilities: About 30 community members gathered Wednesday for a presentation that Watauga County Schools administrators hope will put wheels in motion for a technology initiative for K-8 students."?Watauga Democrat: Boone, NC?9/21
"The New York PD wants to help find your iPhone: Police at 5th Ave. Apple Store to register new iDevices, will do Android too."?Ars Technica?9/21
Non-Apple News
"Nintendo teases Wii U Gamecube downloads"?TG Daily?9/21
"Xperia Ion Ice Cream Sandwich update rolls out"?TG Daily?9/21
"Sony explains lack of 12 GB PS3 in US"?TG Daily?9/21
"Scottish researchers develop software that allows humans to talk to robots"??9/21
"Who Steve Case is betting on now: Tech's slightly graying elder statesman is not so bullish on major media companies."?Fortune?9/21
"Winklevoss twins steer new course"?Financial Times [Paid Membership Required]?9/21
"More Boeing planes to get wireless, cellular connectivity"?PCWorld?9/21
"RIM updates BlackBerry Mobile Fusion device management suite"?ZDNet?9/21
"RIM CEO Apologizes For Yet Another BlackBerry Outage, Details How Many Users Affected"?TechCrunch?9/21
"RIM fixes BlackBerry outage that hit Europe, Middle East, Africa"?CNET News?9/21
"Google Apps users get email and contacts migration tool"?ZDNet?9/21
"Q&A: Google's VP of enterprise Amit Singh at Dreamforce '12"?ZDNet?9/21
"Google shuts once-feted China music download service"?Reuters?9/21
Publications/Podcasts
"5by5 | The Critical Path #55: Gravity Well"?asymco?9/22
"Gene Steinberg meets Alexander Adam, from Quasado, Mac|Life columnist Adrian Hoppel, and The Mac Observer's John Martellaro this week on The Tech Night Owl LIVE!"?The Tech Night Owl LIVE?9/21
"Hossein Yassaie: Meet the man with the big Imagination/The technology chief played a vital role in developing Apple's new iPhone5 ? but there is a lot more to come, he tells Gideon Spanier"?The Independent?9/21
"David Pogue: iPhone Improved in Every Possible Way/New York Times technology columnist David Pogue and Daring Fireball tech blogger John Gruber discuss the iPhone 5." [Video Report]?Bloomberg?9/21
"iPhone 5 Ships! Selling your iPhone, Apple Care, Maps (Podcast)"?Insanely Great Mac?9/21
"iPhone 5 camera powered by Sony sensor: Photography is ever more important in smartphone usage, and a close-up view shows that Sony got the coveted spot supplying the sensor for Apple's new smartphone."?CNET News?6:50 AM
"iPhone 5 jailbroken, but not yet available for us"?Crave @ CNET?6:58 AM
"Cracked! Hacker Claims to Jailbreak the iPhone 5."?AllThingsD?9/22
"Some iPhone 5 orders arriving with cosmetic damage"?Electronista?9/22
"iPhone 5 Users Reporting Yellow Tint On Their Displays [PHOTOS]?Redmond Pie?9/22
"Apple A6 Die Revealed: 3-core GPU, AnandTech?9/21
"Confirmed: Apple's A6 uses triple-core GPU/It's the same GPU as in the iPhone 4S, there's just more of it."?Ars Technica?9/21
"Could Apple's A6 be a 'big-little' processor?"?EE Times?9/21
"iPhone 5 More Repairable than iPhone 4, 4S, Says iFixit"?eWeek?9/21
"Apple can replace broken iPhone 5 screens in the store, says report"?CNET News?9/21
"The Verizon iPhone 5 is GSM unlocked, tested with AT&T"?iDownload Blog?9/21
"Amid record retail launch, iPhone 5 online ship times slip to four weeks"?Tap For Mobile?9/21
"Google homes in on Maps app for iOS 6, report says: The company is reportedly working on a Google Maps app, but there is rampant confusion over whether it was actually submitted for approval in the Apple App Store yet."?CNET News?9/21
"The Apple iPhone 5 has reportedly been jailbroken"?The Next Web?9/21
"The iPhone 5 lets you put 16 apps inside a folder"?iDownload Blog?9/21
"Researchers hack iPhone, steal data: White-hat hackers broke into the developer version of iOS 6, meaning Apple's new iPhone 5 could be vulnerable"?CSO?9/21
"Asian Suppliers of iPhone Components Scramble to Meet Orders"?WSJ.com [Paid Membership Required]?9/21
"Apple Cuts Display Orders to Samsung, Loses Patent Case in Germany"?Patently Apple?9/21
"Taiwan market: Parallel-imported iPhone 5 available for sale at 40-50% higher prices, says newspaper"?DigiTimes?9/21
"PSA: Don't leave negative reviews for non-widescreen apps -- developers are updating as fast as they can!"?iMore?9/21
"iPhone 5 Unboxing - Both Black and White Models - AKA the obligatory iPhone unboxing (Video)"?Insanely Great Mac?9/21
"The iPhone 5 Gets Unboxed"?Mashable?9/21
"iPhone OS 3: Let's Build an App List"?Low End Mac?9/21
AppleCare/Helps
"iBooks and iBookstore: Parental Controls in iOS 6"?Apple Support?9/22
"Developers claim Safari in iOS 6 breaks Web apps with aggressive caching: The HTTP specification says one thing, Safari does another."?Ars Technica?9/21
"How to Clean Your MacBook Safely and Effectively"?Mactuts+?9/21
Price Trackers/Deals
"There are no new item in The US Apple Store, 99 were unchanged, and seven were Sold Out."?While Supplies Last?6:52 AM
"Velocispider For iPhone and iPad Is Temporarily Available For Free (Normally $2.99)"?Apple Sliced?9/22
"Hanger For iPhone Is Free Right Now (Previously $0.99)"?Apple Sliced?9/22
"R-Tech Commander Colony For iPhone Is Free Today (Was $0.99)"?Apple Sliced?9/22
"There are no new item in The US Apple Store, 106 were unchanged, and one was Sold Out."?While Supplies Last?9/22
"iPhone Buyer's Guide... $0 To $950 - The Best iPhone Prices, Deals, Reviews And Information"?MacReviewZone?9/22
"ProCam For iPhone Is Temporarily Available For Free (Normally $0.99)"?Apple Sliced?9/21
"Don't Run With a Plasma Sword For iPhone and iPad Is Free Right Now (Previously $1.99)"?Apple Sliced?9/21
"Battle Monkeys For iPhone and iPad Is Free Today (Was $1.99)"?Apple Sliced?9/21
"iPad (2012) Prices & Sales"?MacPrices?9/21
"MacBook Air Prices & Sales"?MacPrices?9/21
"MacBook Pro Prices & Sales"?MacPrices?9/21
"Refurbished MacBook Air from $679, free shipping, Mountain Lion"?FairerPlatform?9/21
Deal Brothers Daily Deal: Mac mini 2.5GHz dual-core Intel Core i5:? $1189.00 Delivered
Reviews
"Apple iPhone 5's A6 Outshines Rivals in Performance Tests: Apple iPhone 5 is said to have a tri-core PowerVR SGX 543MP3 GPU running at a higher speed"?International Business Times?6:57 AM
"Apple's iPhone 5 outperforms Android Galaxy S III and RAZR M"?TG Daily?6:49 AM
"iPhone 5 Camera Battle: Is It the Best Smartphone Shooter?"?Gizmodo?9/22
"iPhone 5: The First Hour"?SplatF?9/22
"Apple iPhone 5 first impressions: Beauty is in the hand of the beholder"?ZDNet?9/22
"iPhone 5 review: Apple's latest smartphone gets a bigger screen, LTE, and more power ? but does it keep the crown?"?The Verge?9/21
"Watch This: Josh demos the iPhone 5 on Late Night with Jimmy Fallon"?The Verge?9/21
"Review: Style triumphs over substance in iPhone 5"?Boston Herald?9/21
"iPhone 5 Teardown"?iFixit?9/21
"Shootout: iPhone 5 versus iPhone 4S, iPhone 4, and Galaxy S III"?Bare Feats?9/21
"Hands on with the iPhone 5"?Macworld?9/21
"iPhone 5: First Thoughts And Random Impressions"?MacStories?9/21
"iPhone 5 Benchmarks: 30% to 160% Faster than iPhone 4S"?The Mac Observer?9/21
"What's The Difference -Comparing The iPhone 5 to the iPhone 4S and iPhone 4"?MacReviewZone?9/21
"Kindle Fire HD vs. iPad: How does the new Kindle Fire HD compare with the best tablet on the block?"?CNET Reviews?9/21
"Review: First crop of iPhone 5 cases available now"?GigaOM?9/21
"DaVinci Resolve: Which GPU provides the best acceleration on the Mac Pro?"?Bare Feats?9/21
iPad/iPhone/iPod touch Apps
"Local search Field Test: Apple Maps vs. Google Maps/In part two of our Apple Maps app testing, we decided to perform local searches of landmarks and other locations and the results were clearly lopsided."?CNET Reviews?9/21
"Review: iPhone 5"?Gizmag?9/21
"Lab Tests: iOS 6 and iOS 5 performance differences"?Macworld?9/21
"iOS App Review: Layout brings collages into the iPad age"?Macworld?9/21
"MacMost Now 764: iOS 6 Maps App Turn-By-Turn Directions"?MacMost?9/21
"iOS 6 Maps Got You Down? Navigon may be your answer!"?Best App Site?9/21
"'Jasmine' is the YouTube iPhone app you should be using (from the developer of Alien Blue)"?VentureBeat?9/21
"Review -Savi Contacts: a Great Substitute for iOS 6 Users"?The Mac Observer?9/21
"Penultimate: Just Shy Of The Ultimate iPad Note Taking App"?The Mac Observer?9/21
"This Week in Apps I Like ? National Parks, The Photo Cookbook, Paper, Articles, IncrediBooth"?7/Apps Blog?9/21
"iOS Game Review: Battles will charm you in Outwitters"?Macworld?9/21
"Jewel Factory Review"?148Apps?9/21
"Epic Adventures: La Jangada Review"?148Apps?9/21
How-To/Tutorial
"How to Downgrade Back to iOS 5"?Mac|Life?9/21
"How to Transfer Everything from Old iPhone to New iPhone 5 the Easy Way"?OS X Daily?9/21
"Get started with the iPhone 5"?Macworld?9/21
"So You Just Got an iPhone 5... Let's Get Started"?Touch Arcade?9/21
"Uploading an iDVD to Youtube"?iLifeHelp?9/21
Tips
"iOS 6: Messages Now Automatically Selects Last-Used International Keyboard For Each Contact"?MacStories?9/22
"The Grand Central Apple Store Reportedly Has No Lines, And Plenty Of iPhones"?Business Insider?9/21
"Updated: Top 12 ways to trade old iPhones for cash now that you have your iPhone 5"?9 to 5 Mac?9/21
"iOS 6: Talking to Siri and saying 'hi'"?TUAW?9/21
"Get Weather on iPad with the Clock App"?OS X Daily?9/21
"Here's where to get LTE on your iPhone 5"?The Verge?9/21
"Watch out! iOS 6 can jack up your phone bill?Steer clear of sticker shock?follow these steps to disable the iO6 features that can eat up your iPhone or iPad's data plan"?InfoWorld?9/21
"The iPhone 5 Weather app can function as a world clock"?iDownload Blog?9/21
"Get Siri to tell you the temperature in centigrade"?Mac OS X Hints?9/21
"Want an iPhone 5 today? Go to a carrier store"?VentureBeat?9/21
"How to get an iPhone 5 with unlimited data"?CNNMoney?9/21
"So you hate iOS 6 Maps? Here are your best alternative options"?Digital Trends?9/21
"Hate iOS 6 Maps? Here's What To Do ..."?Forbes?9/21
"Don't Like the iOS 6 Podcasts App? Get Rid of It"?Kirkville?9/21
"How to track your iPhone 5 delivery if you're in the UK"?iMore?9/21
"iPhone 6 release date: iPhone 5S scenario says you're not going anywhere for awhile."?Beatweek Magazine?7:02 AM
"Samsung drags iPhone 5 into never-ending legal battle"?Crave @ CNET?6:59 AM
"Apple (AAPL) vs Samsung, Looks Like We'll Be Doing This All Over Again"?Wall Street Pit?6:59 AM
"The iPhone 5 front is not flush with the frame"?Fayez Mohamood?6:46 AM
"Apple: Sympathy for iOS 6 Maps"?Barron's?9/22
"iOS 6 maps has wrong location for Apple Store"?The Register?9/22
"Apple's iPhone 5: The Chinatown factor"?Fortune?9/22
"Is Apple's new maps app upsetting? The OpenForum chimes in: Apple ditched Google for maps, and many users are upset."?Ars Technica?9/22
"Why maps matter to Apple, Google and others"?TechHive?9/22
"The Macalope Weekly: Seen it"?Macworld?9/22
"In Apple-Google maps war, consumers lose"?MarketWatch?9/22
"LTE Prime Time: Four Unexpected Ways to Play the iPhone 5"?Barron's?9/22
"Apple And That Swiss Train Watch"?Forbes?9/22
"A Flawed Samsung and iPhone Drop Test (the Galaxy Lost)"?eXtensions?9/22
Those of us who love our pens know that they can be more than just a writing instrument that we toss out and replace with a new one?they can be great tools that help us work and feel more creative. That said, most of us don't want to drop hundreds of dollars on a pen if we don't have to, so this week we asked you which budget pens were the ones you make sure never to let someone borrow and walk away with. Let's take a look at the top five, based on your nominations. 
So you've got a shiny new iPhone 5, but you're already sick of the default "water ripple" wallpaper, and those old iPhone 4 wallpapers are too small. The web may not be teeming with iPhone 5-sized wallpapers yet, but here's where you can find one that suits your tastes?and how to crop one for yourself. 
The newest bundle of DRM-free ebooks from StoryBundle is available now, this time focusing on the crime and thriller genre. As mentioned last time, StoryBundle offers packages of quality indie books for a pay-what-you-like pricetag, vetted and brought to you by former Lifehacker Jason Chen. [StoryBundle]
Eyes wide open, forging ahead.
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Public release date: 24-Sep-2012
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